About
Dr. Rhys Callahan applies cryo-electron microscopy to visualize peptide-receptor interactions at near-atomic resolution. His structural insights have guided rational design of next-generation peptide therapeutics.
Summary
Solved the first high-resolution structure of a triple-agonist peptide bound to all three target receptors simultaneously.
Key Lessons
A months-long crystallization failure led him to pioneer cryo-EM approaches for flexible peptide complexes that traditional crystallography could not resolve.
Certifications
- Ph.D. Biochemistry, University of Chicago
- Protein Society Member
- Howard Hughes Investigator
Areas of Expertise
- Cryo-EM peptide structures
- Conformational analysis
- Receptor-peptide complexes